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Serum proteomic profiling of patients with compensated advanced chronic liver disease with and without clinically significant portal hypertension.

Frane PaštrovicRudjer NovakIvica GrgurevićStela HrkacGrgur SalaiMarko ŽarakLovorka Grgurevic
Published in: PloS one (2024)
We propose that altered inflammatory response, including NET formation, vascular contractility and formation of new lymph vessels are key steps in PH development. Proteins such as CD44, VEGF-C, LYVE-1, tenascin C, Plasminogen activator inhibitor 1, Nephronectin, Bactericidal permeability-increasing protein, Autotaxin, Myeloperoxidase and a disintegrin and metalloproteinase with thrombospondin motifs-like protein 4 might be considered for further validation as potential therapeutic targets and candidate biomarkers of CSPH in cACLD.
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