Development of a T cell-redirecting bispecific antibody targeting B-cell maturation antigen for the suppression of multiple myeloma cell growth.
Jianxin HuoYuhan HuangZiying ZhengXin Ni TayFarouq Bin MahfutWei ZhangKong-Peng LamSteven C L HoShengli XuPublished in: Antibody therapeutics (2022)
Our results suggest that the BCMA × CD3 bsAb in the FabscFv format can efficiently inhibit MM cell growth and have promising potential to be developed into a therapeutic antibody drug for the treatment of MM.