Attenuated Cytokine-Induced Memory-Like Natural Killer Cell Responses to Mycobacterium tuberculosis in Tuberculosis Patients.
Chen LiangShanshan LiJinfeng YuanYanhua SongWeicong RenWei WangYuanyuan ShangShenjie TangYu PangPublished in: Infection and drug resistance (2023)
CIML NK cells from healthy individuals exist the increased ability of IFN-γ secretion and boosted anti-MTB activity in vitro, which from TB patients show impaired IFN-γ production and no enhanced anti-MTB activity compared to those from healthy donors. Additionally, we observe the poor expansion potential of CIML NK cells co-stimulated with antigens from MTB. These results open up new possibilities for NK cell-based anti-tuberculosis immunotherapeutic strategies.
Keyphrases
- mycobacterium tuberculosis
- nk cells
- pulmonary tuberculosis
- end stage renal disease
- ejection fraction
- newly diagnosed
- chronic kidney disease
- peritoneal dialysis
- prognostic factors
- immune response
- stem cells
- emergency department
- single cell
- minimally invasive
- hepatitis c virus
- diabetic rats
- patient reported
- climate change
- endothelial cells
- bone marrow
- oxidative stress
- antiretroviral therapy