CircTUBD1 Regulates Radiation-induced Liver Fibrosis Response via a circTUBD1/micro-203a-3p/Smad3 Positive Feedback Loop.

Hao NiuLi ZhangBiao WangGuang-Cong ZhangJuan LiuZhi-Feng WuShi-Suo DuZhao Chong Zeng

Published in: Journal of clinical and translational hepatology (2022)

This study is the first to reveal the mechanism and role of circTUBD1 in RILF via a circTUBD1/micro-203a-3p/Smad3 feedback loop, which provides a novel therapeutic strategy for relieving the progression of RILF.

Keyphrases

radiation induced
liver fibrosis
epithelial mesenchymal transition
transforming growth factor
radiation therapy
transcription factor
genome wide
single cell
gene expression
dna methylation