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Immunosuppressive CD29 + Treg accumulation in the liver in mice on checkpoint inhibitor therapy.

Benjamin L GreenYuta MyojinChi MaBenjamin RufLichun MaQianfei ZhangUmberto RosatoJonathan QiMahler RevsineSimon WabitschKylynda BauerMohamed-Reda BenmebarekJustin McCallenAmran NurXin WangVivek SehraRevant GuptaManfred ClaassenXin Wei WangFirouzeh KorangyTim F Greten
Published in: Gut (2023)
Tregs constitute a unique subpopulation of hepatic Tregs that are primed to respond to ICI agents and mediate resistance.
Keyphrases
  • dna damage
  • cell cycle
  • high fat diet induced
  • nk cells
  • type diabetes
  • oxidative stress
  • cell proliferation
  • wild type
  • cell therapy
  • bone marrow