Regional Differences in Gamma-Aminobutyric Acid and Glutamate Concentrations in the Healthy Newborn Brain.

Sudeepta K Basu S Pradhan Scott D Barnett Mark Mikkelsen Kushal Kapse J Murnick J L Quistorff C A Lopez Adre du Plessis Catherine Limperopoulos

Published in: AJNR. American journal of neuroradiology (2021)

We report normative regional variations and temporal trends of in vivo gamma-aminobutyric acid and glutamate concentrations reflecting the functional and maturational status of 3 distinct brain regions of the neonate. These measures will serve as important normative values to allow early detection of subtle neurometabolic alterations in high-risk neonates.

Keyphrases

resting state
white matter
functional connectivity
cerebral ischemia
low birth weight
preterm birth