BORIS/CTCFL epigenetically reprograms clustered CTCF binding sites into alternative transcriptional start sites.
Elena M PugachevaDharmendra Nath BhattSamuel Rivero-HinojosaMd TajmulLiron FedidaEmma PriceYon JiDmitri LoukinovAlexander V StrunnikovBing RenVictor V LobanenkovPublished in: Genome biology (2024)
Thus, BORIS functions as a transcription factor that epigenetically reprograms clustered CTCF binding sites into transcriptional start sites, promoting transcription from alternative promoters in both germ cells and cancer cells.