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Placental growth factor promotes neural invasion and predicts disease prognosis in resectable pancreatic cancer.

Andreas GöhrigGeorg HilfenhausFriederike RosseckMartina WelzelBenjamin MoserGianluca BarboneCatarina Alisa KunzeJohannes ReinGregor WilkenMichael BöhmigThomas MalinkaFrank TackeMarcus BahraKatharina M DetjenChristian Fischer
Published in: Journal of experimental & clinical cancer research : CR (2024)
Our translational results highlight PlGF as an axon guidance factor, which fosters neurite outgrowth and attracts tumor cells towards nerves. Hence, PlGF represents a promising circulating biomarker of NI and potential therapeutic target to improve the clinical outcome for patients with resectable PDAC.
Keyphrases
  • growth factor
  • locally advanced
  • liver metastases
  • cell migration
  • rectal cancer
  • squamous cell carcinoma
  • human health
  • radiation therapy
  • optic nerve
  • risk assessment
  • metal organic framework
  • climate change