Clinical, histological and molecular profiling of different stages of alcohol-related liver disease.
Meritxell Ventura-CotsJosepmaria ArgemiPatricia D JonesCarolin LacknerMohamed El HagJuan G AbraldesEdilmar AlvaradoAna ClementeSamhita RaviAntonio AlvesMohamed AlboraieJose AltamiranoSergio BaraceFrancisco BosquesRobert BrownJuan CaballeriaJoaquin CabezasSofia CarvalhanaHelena Cortez-PintoAdilia CostaDelphine DegréCarlos Fernandez-CarrilloNathalie Ganne-CarrieGuadalupe Garcia-TsaoJoan GenescaJohn KoskinasNicolas LanthierAlexandre LouvetJuan José LozanoMichael R LuceySteven MassonPhilippe MathurinNahum Mendez-SanchezRosa MiquelChristophe MorenoTaofic MounajjedGemma OdenaWon KimPau Sancho-BruR Warren SandsJustyna SzafranskaLaurine VersetBern SchnablChristine SempouxVijay ShahDebbie Lindsay ShawcrossRudolf E StauberBeate K StraubElizabeth VernaDina TiniakosEric TrépoVictor VargasCàndid VillanuevaJohn T WoosleyMarianne ZiolSebastian MuellerPeter StärkelRamon A BatallerPublished in: Gut (2022)
Despite comparable alcohol intake, AH patients presented with worse liver function compared with ndALD patients. Bilirubinostasis, severe fibrosis and ductular reaction were prominent features of AH. AH patients exhibited a more profound deregulation of gene expression compared with ndALD patients.