Synthesis of Mesoporous Silica Coated Gold Nanorods Loaded with Methylene Blue and Its Potentials in Antibacterial Applications.
Adrian Fernández-LodeiroJamila DjafariJavier Fernández LodeiroMaria Paula DuarteElisabete Muchagato MauricioJosé-Luis Capelo-MartínezCarlos LodeiroPublished in: Nanomaterials (Basel, Switzerland) (2021)
In this work, the successful preparation and characterization of gold nanorods (AuNRs) coated with a mesoporous silica shell (AuNRs@Simes) was achieved. Conjugation with methylene blue (MB) as a model drug using ultrasound-stimulated loading has been explored for further application in light-mediated antibacterial studies. Lyophilization of this conjugated nanosystem was analyzed using trehalose (TRH) as a cryogenic protector. The obtained stable dry formulation shows potent antimicrobial activity against Gram-negative (Escherichia coli) and Gram-positive (Staphylococcus aureus) bacteria after a simple post-treatment irradiation method with a red laser during a short time period.
Keyphrases
- gram negative
- silver nanoparticles
- multidrug resistant
- staphylococcus aureus
- escherichia coli
- drug delivery
- anti inflammatory
- reduced graphene oxide
- magnetic resonance imaging
- klebsiella pneumoniae
- photodynamic therapy
- computed tomography
- cancer therapy
- combination therapy
- radiation induced
- high speed
- smoking cessation
- electronic health record
- pseudomonas aeruginosa