BRAF gene mutations in synchronous papillary thyroid carcinoma and Langerhans cell histiocytosis co-existing in the thyroid gland: a case report and literature review.
Mohammad Abdelqader Al HamadHassan M AlbisherWeam R Al SaeedAhmed T AlmumtinFatimah M AllabbadMohammed A ShawarbyPublished in: BMC cancer (2019)
The coexistence of a PTC with LCH harboring BRAF mutation may suggest etiologic relation between the two conditions that involves the BRAF gene. Clinically, it may suggest an aggressive, locally advanced thyroid cancer, an impression that may reflect on the selected surgical management, chemotherapy and BRAF mutation-targeting therapy to these patients.
Keyphrases
- locally advanced
- metastatic colorectal cancer
- end stage renal disease
- wild type
- ejection fraction
- rectal cancer
- squamous cell carcinoma
- newly diagnosed
- chronic kidney disease
- peritoneal dialysis
- prognostic factors
- single cell
- lymph node metastasis
- radiation therapy
- clinical trial
- cancer therapy
- stem cells
- phase ii study
- gene expression
- mesenchymal stem cells
- copy number
- study protocol
- transcription factor
- double blind