123I-FP-CIT SPECT [(123) I-2β-carbomethoxy-3β-(4-iodophenyl)-N-(3-fluoropropyl) nortropane single photon emission computed tomography] Imaging in a p.A53T α-synuclein Parkinson's disease cohort versus Parkinson's disease.

Christos KorosAthina SimitsiAndreas PrentakisIon BeratisDimitra PapadimitriouDionysia KontaxopoulouStella FragkiadakiNikolaos PapagiannakisJohn SeibylKenneth MarekSokratis G PapageorgiouXenia Geronicola TrapaliMaria StamelouLeonidas Stefanis

Published in: Movement disorders : official journal of the Movement Disorder Society (2018)

PD patients harboring the p.A53T SNCA mutation show evidence of a more severe nigrostriatal denervation, especially evident in the caudate nucleus. The lack of significant differences in the putaminal binding ratios may reflect a floor effect or a true preferential targeting of the caudate terminals in p.A53T SNCA-associated PD. © 2018 International Parkinson and Movement Disorder Society.

Keyphrases

computed tomography
end stage renal disease
chronic kidney disease
newly diagnosed
high resolution
magnetic resonance imaging
early onset
prognostic factors
peritoneal dialysis
drug delivery
magnetic resonance
cancer therapy
patient reported outcomes
drug induced
patient reported