The control of DNA repair by the cell cycle.
Nicole HustedtDaniel DurocherPublished in: Nature cell biology (2017)
The correct duplication and transmission of genetic material to daughter cells is the primary objective of the cell division cycle. DNA replication and chromosome segregation present both challenges and opportunities for DNA repair pathways that safeguard genetic information. As a consequence, there is a profound, two-way connection between DNA repair and cell cycle control. Here, we review how DNA repair processes, and DNA double-strand break repair in particular, are regulated during the cell cycle to optimize genomic integrity.
Keyphrases
- dna repair
- cell cycle
- dna damage
- cell proliferation
- copy number
- dna damage response
- genome wide
- induced apoptosis
- cell cycle arrest
- oxidative stress
- single cell
- stem cells
- healthcare
- gene expression
- intellectual disability
- circulating tumor
- cell therapy
- dna methylation
- health information
- cell free
- mesenchymal stem cells
- signaling pathway
- pi k akt