Anti-KIT monoclonal antibody CDX-0159 induces profound and durable mast cell suppression in a healthy volunteer study.
Diego AlvaradoMarcus MaurerRichard GedrichScott B SeibelMichael B MurphyLinda CrewJoel GoldsteinAndrea CrockerLaura A VitalePamela A MoraniLawrence J ThomasThomas R HawthorneTibor KelerDiane YoungElizabeth CrowleyMartin KankamMargo Heath-ChiozziPublished in: Allergy (2022)
CDX-0159 administration leads to systemic mast cell ablation and may represent a safe and novel approach to treat mast cell-driven disorders.