Host genetic background regulates the capacity for anti-tumor antibody-dependent phagocytosis.

James E GlassbrookJustin B HackettMaria C MuñizMadeline BrossGreg DysonNasrin MovahhedinAlexander UllrichHeather M Gibson

Published in: bioRxiv : the preprint server for biology (2023)

Host genetics play a key regulatory role in targeted immunotherapy outcomes, and putative causal genes are identified in murine chromosome 10 which may govern Mφ function during ADCP.

Keyphrases

genome wide
copy number
transcription factor
cancer therapy
genome wide identification
gene expression
bioinformatics analysis
genome wide analysis