Multienzyme Active Nanozyme for Efficient Sepsis Therapy through Modulating Immune and Inflammation Inhibition.
Qi XinShaofang ZhangSi SunNan SongYadong ZheFangzhen TianShu ZhangMeili GuoXiao-Dong ZhangJianning ZhangHao WangRuiping ZhangPublished in: ACS applied materials & interfaces (2024)
Sepsis, a life-threatening condition caused by a dysregulated immune response to infection, leads to systemic inflammation, immune dysfunction, and multiorgan damage. Various oxidoreductases play a very important role in balancing oxidative stress and modulating the immune response, but they are stored inconveniently, environmentally unstable, and expensive. Herein, we develop multifunctional artificial enzymes, CeO 2 and Au/CeO 2 nanozymes, exhibiting five distinct enzyme-like activities, namely, superoxide dismutase, catalase, glutathione peroxidase, peroxidase, and oxidase. These artificial enzymes have been used for the biocatalytic treatment of sepsis via inhibiting inflammation and modulating immune responses. These nanozymes significantly reduce reactive oxygen species and proinflammatory cytokines, achieving multiorgan protection. Notably, CeO 2 and Au/CeO 2 nanozymes with enzyme-mimicking activities can be particularly effective in restoring immunosuppression and maintaining homeostasis. The redox nanozyme offers a promising dual-protective strategy against sepsis-induced inflammation and organ dysfunction, paving the way for biocatalytic-based immunotherapies for sepsis and related inflammatory diseases.
Keyphrases
- oxidative stress
- immune response
- septic shock
- diabetic rats
- acute kidney injury
- intensive care unit
- signaling pathway
- ischemia reperfusion injury
- reactive oxygen species
- dna damage
- induced apoptosis
- hydrogen peroxide
- drug delivery
- dendritic cells
- sensitive detection
- bone marrow
- toll like receptor
- gold nanoparticles
- cancer therapy
- high glucose
- nitric oxide
- drug induced
- replacement therapy
- heat shock
- stress induced