Antithrombin, PC (Protein C), and PS (Protein S): Genome and Transcriptome-Wide Association Studies Identify 7 Novel Loci Regulating Plasma Levels.
Yuekai JiGerard Temprano-SagreraLori A HolleAllison BeboJennifer A BrodyNgoc-Quynh LeKadri KangroMichael R BrownAngel Martinez-PerezColleen M SitlaniPierre SuchonMarcus E KleberDavid B EmmertAyse Bilge OzelDre'Von A DobsonWeihong TangDolors LlobetRussell P TracyJean-François DeleuzeGraciela E DelgadoMartin GogeleKerri L WigginsJuan Carlos Carlos SoutoJames S PankowKent D TaylorDavid Alexandre TrégouëtAngela P MoisslChristian FuchsbergerFrits Richard RosendaalAlanna C MorrisonJosé Manuel SoriaAndrea N EdgintonPierre-Emmanuel MorangeWinfried MärzAndrew A HicksKarl C DeschAndrew Danner JohnsonPaul S de VriesAlisa S WolbergNicholas L SmithMaria Sabater-LlealPublished in: Arteriosclerosis, thrombosis, and vascular biology (2023)
The use of larger sample sizes, diverse populations, and a denser imputation reference panel allowed the detection of 7 novel genomic loci associated with plasma antithrombin, PC, and PS levels.