A Novel Tryptanthrin Derivative D6 Induces Apoptosis and DNA Damage in Non-small-cell Lung Cancer Cells Through Regulating the EGFR Pathway.
Haitao LongGuanglong ZhangYue ZhouLiqing QinDanxue ZhuJiayi ChenBo LiuHuayuan TanDanping ChenZhurui LiChengpeng LiZhen-Chao WangPublished in: Anti-cancer agents in medicinal chemistry (2024)
D6 demonstrated significant antitumor activity against A549 cells by inhibiting the EGFR signaling pathway, inducing DNA damage, and subsequently leading to oxidative stress, apoptosis, and cell cycle arrest. Our findings suggest that D6 exhibits potential as an NSCLC drug, owing to its attributes such as antiproliferative activity and ability to induce apoptosis by attenuating the EGFR-mediated signaling pathway.
Keyphrases
- cell cycle arrest
- pi k akt
- dna damage
- signaling pathway
- small cell lung cancer
- oxidative stress
- epidermal growth factor receptor
- induced apoptosis
- cell death
- tyrosine kinase
- dna repair
- cell proliferation
- advanced non small cell lung cancer
- epithelial mesenchymal transition
- brain metastases
- single cell
- ischemia reperfusion injury
- emergency department
- risk assessment
- electronic health record
- heat shock protein
- water soluble