Methotrexate and BAFF interaction prevents immunization against TNF inhibitors.

Samuel BitounGaetane NocturneBineta LyRoman KrzysiekPierre RoquesAlain PruvostAudrey PaolettiJuliette PascaudPierre DönnesKimberly FlorenceAude GleizesAgnes Hincelin-MeryMatthieu AllezSalima Hacein-Bey-AbinaFabienne MackayMarc PallardyRoger Le GrandXavier Mariette

Published in: Annals of the rheumatic diseases (2018)

MTX and BAFF interact in mice where CD73, adenosine and regulatory B cells were identified as key actors in this phenomenon. MTX and BAFF also interact in patients to prevent ADA formation.

Keyphrases

end stage renal disease
ejection fraction
chronic kidney disease
newly diagnosed
rheumatoid arthritis
prognostic factors
metabolic syndrome
patient reported