[Features of genetic manifestations in patients with abdominal obesity during atrial fibrillation in combination with arterial hypertension].
L D HidirovaD A YakhontovVladimir N MaksimovPublished in: Terapevticheskii arkhiv (2021)
In men with AF and AH, single nucleotide polymorphisms rs1378942 of the CSK gene and rs2200733 of chromosome 4q25 are associated with BMI. The heterozygous genotype AC rs1378942 in the CSK gene is significantly more common in patients, regardless of the presence of AO. In the group with AO, the progression of AF occurred 2.57 times more often than in the group without AO.
Keyphrases
- atrial fibrillation
- copy number
- genome wide
- end stage renal disease
- arterial hypertension
- ejection fraction
- newly diagnosed
- chronic kidney disease
- type diabetes
- metabolic syndrome
- insulin resistance
- catheter ablation
- peritoneal dialysis
- oral anticoagulants
- body mass index
- weight gain
- weight loss
- heart failure
- prognostic factors
- gene expression
- patient reported outcomes
- percutaneous coronary intervention
- left atrial appendage
- dna methylation
- skeletal muscle
- transcription factor
- high fat diet induced
- direct oral anticoagulants
- adipose tissue
- acute coronary syndrome