A novel antibody surrogate biomarker to monitor parasite persistence in Trypanosoma cruzi-infected patients.

Maan ZreinElodie GranjonLucie GueyffierJulie CaillaudeauPeter LiehlHans PottelClareci Silva CardosoClaudia Di Lorenzo OliveiraLea Campos de OliveiraTzong-Hae LeeAriela Mota FerreiraAntonio Luiz P RibeiroMichael P BuschEster Cerdeira Sabino

Published in: PLoS neglected tropical diseases (2018)

Ab3 is a new surrogate biomarker that strongly correlates with parasite persistence in chronic and benznidazole-treated Chagas patients. We hypothesize that Ab3 is induced and maintained by incessant stimulation of the immune system by tissue-based and shed parasites that are not consistently detectable by blood based PCR techniques. Hence, a simple immunoassay measurement of Ab3 could be beneficial for monitoring the infectious status of seropositive patients.

Keyphrases

trypanosoma cruzi
end stage renal disease
newly diagnosed
ejection fraction
chronic kidney disease
peritoneal dialysis
prognostic factors
plasmodium falciparum
diabetic rats