Anti-citrullinated protein antibodies with multiple specificities ameliorate collagen antibody-induced arthritis in a time-dependent manner.

Alejandro M GomezR Camille BrewerJae-Seung MoonSuman AcharyaSarah KongpachithQian WangShaghayegh JahanbaniHeidi H WongTobias V LanzZelda Z LoveGundula Min-OoAnita Niedziela-MajkaWilliam H Robinson

Published in: Arthritis & rheumatology (Hoboken, N.J.) (2023)

Recombinant, patient-derived ACPAs ameliorated CAIA. Their anti-inflammatory effects were more preventative than therapeutic. This study highlights a potential protective role for ACPAs in arthritis.

Keyphrases

rheumatoid arthritis
diabetic rats
oxidative stress
protein protein
cell free
risk assessment