International Medullary Thyroid Carcinoma Grading System: A Validated Grading System for Medullary Thyroid Carcinoma.
Ronald A GhosseinTalia L FuchsSara AhmadiMohammed AlghamdiBayan A AlzumailiMohamed Amine BaniEric BaudinAngela ChouAntonio De LeoJames A FaginIan GanlyAnthony Robert GloverDana M HartlChristina KanaanPierre KhneisserFedaa NajdawiAradhya NigamAlexander James PapachristosAndrea RepaciPhilip M SpanheimerErica SolaroliBrian R UntchJustine A BarlettaGiovanni TalliniAbir Al GhuzlanAnthony J GillRonald A GhosseinPublished in: Journal of clinical oncology : official journal of the American Society of Clinical Oncology (2021)
This simple two-tiered international grading system is a powerful predictor of adverse outcomes in MTC. As it is based solely on morphologic assessment in conjunction with Ki67 immunohistochemistry, it brings the grading of MTCs in line with other NETs and can be readily applied in routine practice. We therefore recommend grading of MTCs on the basis of mitotic count, Ki67 proliferative index, and tumor necrosis.