Precision diagnostics of Ewing's sarcoma by liquid biopsy: circulating EWS-FLI1 fusion transcripts.
Matteo AllegrettiBeatrice CasiniChiara MandojStefania BeniniLaurent AlbertiMariangela NovelloElisa MelucciLaura ContiRenato CovelloEdoardo PescarmonaGiuseppe Maria MilanoAlessio AnnovazziVincenzo AnelliVirginia FerraresiRoberto BiaginiPatrizio GiacominiPublished in: Therapeutic advances in medical oncology (2018)
To our knowledge, this is one of the few single-marker LB assays in solid tumors specifically designed to detect rearranged RNAs in blood, and the first study describing EWS circulating tumor RNAs in ES patients. Altogether, our results support the idea that LB may have a considerable impact on ES patient monitoring and management.