Carbapenem-resistant hypervirulent ST23 Klebsiella pneumoniae with a highly transmissible dual-carbapenemase plasmid in Chile.
Matías Gálvez-SilvaPatricio ArrosCamilo Berríos-PasténAura VillamilPaula I RodasIngrid ArayaRodrigo IglesiasPamela ArayaJuan C HormazábalConstanza BohleYahua ChenYunn-Hwen GanFrancisco P ChávezRosalba LagosAndrés E MarcoletaPublished in: Biological research (2024)
We reported the isolation in Chile of high-risk carbapenem-resistant hvKp carrying a highly transmissible conjugative plasmid encoding KPC-2 and VIM-1 carbapenemases, conferring resistance to most beta-lactams. Furthermore, the lack of hypermucoviscosity argues against this trait as a reliable hvKp marker. These findings highlight the rapid evolution towards multi-drug resistance of hvKp in Chile and globally, as well as the importance of conjugative plasmids and other mobile genetic elements in this convergence. In this regard, genomic approaches provide valuable support to monitor and obtain essential information on these priority pathogens and mobile elements.
Keyphrases
- klebsiella pneumoniae
- escherichia coli
- multidrug resistant
- genome wide
- gram negative
- crispr cas
- copy number
- antibiotic resistance genes
- dna methylation
- healthcare
- drug resistant
- gene expression
- health information
- loop mediated isothermal amplification
- microbial community
- wastewater treatment
- sensitive detection
- pseudomonas aeruginosa