Progression of Vertebral Fractures in Patients with Adrenocortical Carcinoma Undergoing Mitotane Therapy.
Deborah CosentiniSalvatore GrisantiJulien HadouxRossella LibèMichele FrigerioMarta LaganàFrederic DeschampsManuel ZampariniLivia LamartinaRebecca PedersiniClara ValsecchiRoberto MaroldiAbir Al GhuzlanMassimo TerzoloRoberto GasparottiEric BaudinAlfredo BerrutiPublished in: The Journal of clinical endocrinology and metabolism (2022)
The administration of mitotane with/without chemotherapy in ACC patients impairs bone health independently from cortisol supplementation. Appropriate preventive measures to decrease the fracture risk should be implemented in these patients.