Metabolic brain changes across different levels of cognitive impairment in ALS: a 18F-FDG-PET study.

Antonio CanosaCristina MogliaUmberto ManeraRosario VastaMaria Claudia TorrieriVincenzo ArenaFabrizio D'OvidioFrancesca PalumboJean Pierre ZucchettiBarbara IazzolinoLaura PeottaAndrea CalvoMarco PaganiAdriano Chiò

Published in: Journal of neurology, neurosurgery, and psychiatry (2020)

These data support the concept that patients with cognitive impairment have a more widespread neurodegenerative process compared with patients with a pure motor disease: the more severe the cognitive impairment, the more diffuse the metabolic changes. Otherwise, metabolic changes related to pure behavioural impairment need further characterisation.

Keyphrases

cognitive impairment
pet ct
positron emission tomography
pet imaging
computed tomography
white matter
early onset
electronic health record
low grade
big data
multiple sclerosis
machine learning
brain injury
resting state