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Effect of Topology on Photodynamic Sterilization of Porphyrinic Metal-Organic Frameworks.

Yao-Yao LiuLi-Jian ChenXu ZhaoXiu-Ping Yan
Published in: Chemistry (Weinheim an der Bergstrasse, Germany) (2021)
Porphyrinic metal-organic frameworks (MOFs) are promising photosensitizers due to the lack of self-aggregation of porphyrin in aqueous solution. However, how the topology of porphyrinic MOFs affects the generation of singlet oxygen (1 O2 ) is unclear. Here, the effect of the topology of porphyrinic MOFs on their photodynamic performance is reported. Four porphyrinic zirconium MOFs (MOF-525, MOF-545, PCN-223 and PCN-224 with different topologies: ftw, csq, shp and she, respectively) were selected to study the influence of topology on the photodynamic antibacterial performance. The 1 O2 generation and the photodynamic antibacterial performance followed an decreasing order of MOF-545>MOF-525>PCN-224>PCN-223. The results reveal that the pore size, the distance between porphyrin, and the number of porphyrin per Zr6 O8 cluster in MOFs greatly affected 1 O2 generation. This work provides guidance for designing new MOFs for efficient photodynamic sterilization.
Keyphrases
  • metal organic framework
  • cancer therapy
  • aqueous solution
  • drug delivery
  • anti inflammatory
  • computed tomography
  • silver nanoparticles
  • single cell
  • wound healing