Interdisciplinary model-informed drug development for extending duration of elagolix treatment in patients with uterine fibroids.
Denise BeckInsa WinzenborgWei GaoNael M MostafaStephanie E ChiuveCharlotte OwensMohamad ShebleyPublished in: British journal of clinical pharmacology (2022)
The elagolix integrated exposure-BMD analysis and translation to fracture risk provided an interdisciplinary model-informed drug development framework for clinical benefit-risk evaluation and enabled approval of longer treatment duration to benefit the patient.
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