Factors Contributing to Fentanyl Pharmacokinetic Variability Among Diagnostically Diverse Critically Ill Children.
Fanuel T HagosChristopher M HorvatAlicia K AuYvette P ConleyLingjue LiSamuel M PoloyacPatrick M KochanekRobert S B ClarkPhilip E EmpeyPublished in: Clinical pharmacokinetics (2020)
In this study we show the feasibility and utility of using electronic record data and remnant blood samples to successfully construct population pharmacokinetic models for a heterogeneous cohort of critically ill children. A clinically relevant effect of concomitant CYP3A4/5 inducers was identified. Scaling this population pharmacokinetic approach is necessary to craft precision approaches to fentanyl administration for critically ill children.
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