Histone acetyltransferase inhibition rescues differentiation of emerin-deficient myogenic progenitors.

Katherine A Bossone Joseph A Ellis James M Holaska

Published in: Muscle & nerve (2020)

We conclude that emerin regulation of HDAC3 activity to affect H4K5 acetylation dynamics is important for myogenic differentiation. Targeting H4K5ac dynamics represents a potential new strategy for ameliorating the skeletal muscle wasting seen in EDMD1.

Keyphrases

skeletal muscle
insulin resistance
histone deacetylase
mouse model
gene expression
metabolic syndrome
human health
wild type