IDH-mutated gliomas promote epileptogenesis through d-2-hydroxyglutarate-dependent mTOR hyperactivation.

Armin MortazaviIslam FayedMuzna BachaniTyrone DowdyJahandar JahanipourAnas KhanJemima OwotadeStuart WalbridgeSara K InatiJoseph SteinerJing WuMark GilbertChun Zhang YangMioara LarionDragan MaricAlexander KsendzovskyKareem A Zaghloul

Published in: Neuro-oncology (2022)

Together, our data suggest that metabolic disruptions in the surrounding cortex due to d-2-HG may be a driving event for epileptogenesis in patients with IDH-mutant gliomas.

Keyphrases

wild type
high grade
low grade
temporal lobe epilepsy
electronic health record
cell proliferation
functional connectivity
fluorescent probe
living cells
aqueous solution
artificial intelligence
single molecule
deep learning