Sirt5 Deficiency Causes Posttranslational Protein Malonylation and Dysregulated Cellular Metabolism in Chondrocytes Under Obesity Conditions.

Shouan ZhuAlbert BatushanskyAnita JopkiewiczDawid MakosaKenneth M HumphriesHolly Van RemmenTimothy M Griffin

Published in: Cartilage (2021)

This study provides the first evidence that Sirt5 broadly regulates chondrocyte metabolism. We observed changes in SIRT5 and MaK levels in cartilage with obesity and joint injury, suggesting that the Sirt5-MaK pathway may contribute to altered chondrocyte metabolism that occurs during OA development.

Keyphrases

oxidative stress
ischemia reperfusion injury
insulin resistance
metabolic syndrome
weight loss
type diabetes
weight gain
high fat diet induced
extracellular matrix
adipose tissue
skeletal muscle
knee osteoarthritis
replacement therapy
small molecule
binding protein
physical activity
protein protein
body mass index