A Compound Containing Aldehyde Dehydrogenase Relieves the Effects of Alcohol Consumption and Hangover Symptoms in Healthy Men: An Open-Labeled Comparative Study.

This open-labeled and comparative study aimed to test the efficacy and safety of a fermented rice extract-based substance containing yeast-fermented powder having aldehyde dehydrogenase (KisLip ® , Pico Entech, Republic of Korea) in healthy male individuals. Healthy male subjects (n = 20) consumed 90 g of alcohol at their first visit. At the second visit, participants consumed 90 g of alcohol or alcohol with a low dose of KISLip ® (2000 mg, KL-L) and then 90 g of alcohol or alcohol with a high dose of KISLip ® (3000 mg, KL-H) at the third visit. The efficacy of KISLip ® depends on the mutational status of important genes related to alcohol metabolism, including alcohol dehydrogenase ( ADH1B ), cytochrome P4502E1 ( CYP2E1 ( 5B ) and CYP2E1 ( 6 )), and aldehyde dehydrogenase ( ALDH2 ). KISLip ® significantly reduced the highest level (Cmax) of alcohol and overall levels of acetaldehyde compared to the alcohol-only group in a dose-dependent manner. These significant effects of KISLip ® on alcohol metabolism were observed independent of mutations in the four genes. In addition, hangover symptoms were significantly decreased in the KISLip ® treated groups. During the study, the participants did not show any adverse events after KISLip ® intake. This clinical study suggested that supplementation of KISLip ® had beneficial effects on alcohol metabolism and might ameliorate the severity of hangovers without any adverse events.