Chloroquine and mefloquine resistance profiles are not related to the circumsporozoite protein (CSP) VK210 subtypes in field isolates of Plasmodium vivax from Manaus, Brazilian Amazon.

Lilian Rose Pratt-RiccioBárbara de Oliveira BaptistaVanessa Rodrigues TorresCesare Bianco-JuniorDaiana de Souza Perce-Da-SilvaEvelyn Kety Pratt RiccioJosué da Costa Lima-JuniorPaulo Renato Rivas TotinoGustavo Capatti CassianoLuciane Moreno Storti-MeloRicardo Luiz Dantas MachadoJoseli de Oliveira-FerreiraDalma Maria BanicLeonardo José de Moura CarvalhoCláudio Tadeu Daniel-Ribeiro

Published in: Memorias do Instituto Oswaldo Cruz (2019)

The VK210 variant is the most frequently observed in the studied region and there is significant genetic variability in the CRR of the P. vivax CSP. Moreover, the antimalarial drug sensitivity profiles of the isolates does not seem to be related to the VK210 subtypes.

Keyphrases

plasmodium falciparum
genetic diversity
genome wide
gene expression
amino acid
dna methylation