DADLE promotes motor function recovery by inhibiting cytosolic phospholipase A2 mediated lysosomal membrane permeabilization after spinal cord injury.

Yituo ChenHaojie ZhangLiting JiangWanta CaiJiaxuan KuangYibo GengHui XuYao LiLiangliang YangYuepiao CaiXiangyang WangZhou-Guang WangWenfei NiKailiang Zhou

Published in: British journal of pharmacology (2023)

DADLE exerts neuroprotective effects on SCI by promoting autophagic flux and inhibiting necroptosis by decreasing LMP via activating DOR/AMPK/SIRT1/p38/cPLA2 pathway.

Keyphrases

signaling pathway
cell death
spinal cord injury
epstein barr virus
skeletal muscle
oxidative stress
ischemia reperfusion injury
cerebral ischemia
brain injury
blood brain barrier
subarachnoid hemorrhage