What is known about the effects of vitamin D in neuropsychiatric lupus?
Thaís Evelyn KarnoppVinicius da Silva FreitasAndressa Leite Di DomenicoGustavo Flores ChapacaisNatália Garcia Dos SantosEduarda Correa FreitasAndrese Aline GasparinOdirlei André MonticieloPublished in: Advances in rheumatology (London, England) (2024)
Systemic lupus erythematosus (SLE) is an autoimmune disease that can affect several organs and systems. The central and/or peripheral nervous system can suffer from complications known as neuropsychiatric lupus (NPSLE). Studies have associated the manifestations of SLE or NPSLE with vitamin D deficiency. It has been shown that hypovitaminosis D can lead to cognition deficits and cerebral hypoperfusion in patients with NPSLE. In this review article, we will address the main features related to vitamin D supplementation or serum vitamin D levels with neuropsychiatric manifestations, either in patients or in animal models of NPSLE.
Keyphrases
- systemic lupus erythematosus
- disease activity
- end stage renal disease
- newly diagnosed
- rheumatoid arthritis
- ejection fraction
- chronic kidney disease
- traumatic brain injury
- multiple sclerosis
- peritoneal dialysis
- prognostic factors
- subarachnoid hemorrhage
- mild cognitive impairment
- white matter
- brain injury
- case control
- patient reported