Neuroinflammation and Tau Colocalize in vivo in Progressive Supranuclear Palsy.
Maura MalpettiLuca PassamontiTimothy RittmanP Simon JonesPatricia Vázquez RodríguezW Richard Bevan-JonesYoung T HongTim D FryerFranklin I AigbirhioJohn T O'BrienJames B RowePublished in: Annals of neurology (2020)
We show that tau pathology and neuroinflammation colocalize in PSP, and that individual differences in subcortical tau pathology and neuroinflammation are linked to clinical severity. Although longitudinal studies are needed to determine causal associations between these molecular pathologies, we suggest that the combination of tau- and immune-oriented strategies may be useful for effective disease-modifying treatments in PSP. ANN NEUROL 2020;88:1194-1204.