Metabolomic Signatures Differentiate Immune Responses in Avian Influenza Vaccine Recipients.

Leigh M HowardTravis L JensenJohannes B GollCasey E GelberMatthew D BradleyStacy D SherrodKristen L HoekSandra YoderNatalia Jimenez-TruqueKathryn EdwardsC Buddy Creech

Published in: The Journal of infectious diseases (2024)

Our findings suggest that tryptophan, tyrosine, and nicotinate metabolism are upregulated among IIV-AS03 recipients compared with IIV alone. Metabolites within these pathways may serve as measures of immunogenicity and may provide mechanistic insights for adjuvanted vaccines.

Keyphrases

immune response
kidney transplantation
ms ms
genome wide
dendritic cells
toll like receptor
gene expression
inflammatory response