Novel ABCD1 variant causes phenotype of adrenomyeloneuropathy with cerebral involvement in Ukrainian siblings: first adult hematopoietic stem cell transplantation for ALD in Ukraine: a case report.
Khrystyna ShchubelkaOlga HerasymenkoAndrii BudzynOleksandr LysytsiaAnastasiia RusynOlga OleksykSvitlana TyntaTaras OleksykPublished in: Journal of medical case reports (2024)
This report emphasizes the importance of genetic testing in diagnosing and comprehending the underlying mechanisms of rare genetic disorders, such as AMN with cerebral involvement. The identification of a novel splice site mutation expands our understanding of the genetic landscape of this condition. Additionally, the challenges and complications encountered during the hematopoietic stem cell transplant procedure underscore the need for cautious consideration and personalized approaches in adult ALD patients.
Keyphrases
- hematopoietic stem cell
- end stage renal disease
- subarachnoid hemorrhage
- genome wide
- chronic kidney disease
- ejection fraction
- newly diagnosed
- acute myeloid leukemia
- risk factors
- copy number
- prognostic factors
- cerebral ischemia
- dna methylation
- minimally invasive
- single cell
- patient reported outcomes
- gene expression
- childhood cancer
- autism spectrum disorder
- bioinformatics analysis