Decreased Vascular Pulsatility in Alzheimer's Disease Dementia Measured by Transcranial Color-Coded Duplex Sonography.
Marion OrtnerChristine HauserChristoph SchmadererClaudia MuggenthalerAlexander HapfelmeierChristian SorgJanine Diehl-SchmidAlexander KurzHans FörstlBenno IkenbergKonstantin E KotliarHolger PoppertTimo GrimmerPublished in: Neuropsychiatric disease and treatment (2019)
Our results strengthen the hypothesis that impaired pulsatility could cause impaired amyloid clearance from the brain and thereby might contribute to the development of AD. However, further studies considering other factors possibly influencing amyloid clearance as well as larger sample sizes are needed.