Activated B cells suppress T-cell function through metabolic competition.
Nobuhiko ImahashiRafet BasarYuefan HuangFang WangNatalia BaranPinaki Prosad BanerjeeJunjun LuAna Karen Nunez CortesNadima UpretyEmily EnsleyLuis Muniz-FelicianoTamara J LaskowskiJudy S MoyesMay DaherMayela MendtLucila N KerbauyMayra ShanleyLi LiFrancesca Lorraine Wei Inng LimHila ShaimYe LiMarina KonoplevaMichael GreenJennifer WargoElizabeth J ShpallKen ChenKatayoun RezvaniPublished in: Journal for immunotherapy of cancer (2022)
We have revealed for the first time the immunomodulatory effects of the metabolic activity of activated B cells and their possible role in suppressing antitumor T-cell responses. These findings add novel insights into immunometabolism and have important implications for cancer immunotherapy.
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