Synergistic association of the copper/zinc ratio under inflammatory conditions with diabetic kidney disease in patients with type 2 diabetes: The Asahi Diabetes Complications Study.
Toshiko TakaoHiroyuki YanagisawaMachi SukaYoko YoshidaYukiko OnishiTazu TaharaTakako KikuchiAkifumi KushiyamaMotonobu AnaiKazuyuki TakahashiSayaka Wakabayashi SugawaHiroki YamazakiShoji KawazuYasuhiko IwamotoMitsuhiko NodaMasato KasugaPublished in: Journal of diabetes investigation (2021)
Under an inflammatory initiation signal of elevated serum sTNFαR1 levels, an increase in the Cu/Zn ratio may further exacerbate inflammation and is synergistically associated with a high prevalence of DKD in patients with type 2 diabetes.