Drug Delivery by Controlling a Supramolecular Host-Guest Assembly with a Reversible Photoswitch.

Published in: Chemistry (Weinheim an der Bergstrasse, Germany) (2016)

The reversibly switchable trans-chalcone/flavylium photochromic system was successfully coupled to the complexation equilibrium of a drug-cucurbit[7]uril host-guest assembly. Hence, the phototriggered release of memantine under illumination at 366 nm was observed. The process can be partially reverted through a thermally activated back reaction.

Keyphrases

drug delivery
water soluble
photodynamic therapy
cancer therapy
light emitting
molecular dynamics simulations