Restoration of functional sperm production in irradiated pubertal rhesus monkeys by spermatogonial stem cell transplantation.

Gunapala ShettyJennifer M MitchellJennifer M MeyerZhuang WuTruong N A LamThien T PhanJie ZhangLorraine HillRamesh C TailorKaren A PetersMaria C PenedoCarol HannaKyle E OrwigMarvin L Meistrich

Published in: Andrology (2020)

We confirmed that SSC transplantation can be used for restoration of fertility in male cancer survivors exposed to irradiation as a therapeutic agent. The success rate of this procedure, however, is low. The success of filling the tubules with the cell suspension, but not the GnRH-ant treatment, was related to the level of colonization by transplanted cells.

Keyphrases

stem cell transplantation
high dose
induced apoptosis
cell therapy
cell cycle arrest
single cell
young adults
childhood cancer
stem cells
oxidative stress
radiation therapy
signaling pathway
radiation induced
cell death
replacement therapy