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Molecular Classification of Appendiceal Adenocarcinoma.

Michael B FooteHenry S WalchWalid K ChatilaEfsevia VakianiChris ChandlerFelix SteinrueckeGarrett M NashZsofia K StadlerSebastian K ChungRona YaegerMaria Ignez Freitas Melro BraghiroliJinru ShiaYelena M KemelAnna MaioMargaret SheehanBenoit RousseauGuillem ArgilésMichael F BergerDavid B SolitNikolaus SchultzLuis A DiazAndrea Cercek
Published in: Journal of clinical oncology : official journal of the American Society of Clinical Oncology (2022)
AC molecular patterns identify distinct molecular subtypes: a clinically indolent RAS-mut/GNAS-wt/TP53-wt subtype; a chemotherapy-resistant GNAS-mut predominant subtype; and an aggressive, highly aneuploid TP53-mut predominant subtype. Each subtype exhibits conserved clinical behavior irrespective of histopathology.
Keyphrases
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