Influence of clinical and genetic factors on propofol dose requirements: A genome-wide association study.
Sirkku AhlströmPaula BergmanRitva JokelaKlaus T OlkkolaMari A KaunistoEija A KalsoPublished in: Anesthesiology (2024)
In this first GWAS exploring propofol requirements, we discovered novel genetic associations suggesting new biologically relevant pathways for propofol and general anesthesia. The roles of the gene products of ROBO3/FEZ1, NALCN and KCNJ2 in propofol anesthesia warrant further studies.