Analysis of TP53 aflatoxin signature mutation in hepatocellular carcinomas from Guatemala: A cross-sectional study (2016-2017).
Christian S AlvarezJeremy OrtizGiovanna Bendfeldt-AvilaYi XieMingyi WangDongjing WuHerbert HigsonElisa LeeKedest TeshomeJoaquin BarnoyaDavid E KleinerJohn D GroopmanRoberto OrozcoKatherine A McGlynnEduardo GharzouziMichael DeanPublished in: Health science reports (2020)
The presence of the TP53 R249S mutation in the samples studied suggests that AFB1 may contribute to the high incidence of HCC in Guatemala. The proportion of HBV+ tumors was low, suggesting that AFB1 may be associated with HCC in the absence of concomitant HBV infection. Further investigation of AFB1 and other risk factors for HCC in Guatemala is warranted.