Columbianadin attenuates doxorubicin-induced cardiac injury, oxidative stress, and apoptosis via Sirt1/FOXO1 signaling pathway.
Bo PengLi RaoJiaolong YangXiaowei KuBin KongWei ShuaiHe HuangPublished in: Acta cirurgica brasileira (2023)
Collectively, CBN attenuated oxidative stress and cardiomyocyte apoptosis in DOX-induced cardiotoxicity through maintaining Sirt1/FOXO1 signaling pathway. Our results demonstrated that CBN might be used to treat DOX-related cardiotoxicity.
Keyphrases
- oxidative stress
- diabetic rats
- signaling pathway
- pi k akt
- induced apoptosis
- ischemia reperfusion injury
- cell cycle arrest
- high glucose
- dna damage
- epithelial mesenchymal transition
- transcription factor
- endoplasmic reticulum stress
- drug induced
- endothelial cells
- cell proliferation
- drug delivery
- left ventricular
- angiotensin ii
- heat shock protein