Trajectories of Cognitive Decline in Brain Donors With Autopsy-Confirmed Alzheimer Disease and Cerebrovascular Disease.
Brandon FrankMadeline AllyYorghos TripodisChristian PuzoCaroline LabrioloLandon HurleyBrett MartinJoseph PalmisanoLawrence ChanEric SteinbergKatherine TurkAndrew BudsonMaureen O'ConnorRhoda AuWei Qiao QiuLee GoldsteinWalter KukullNeil KowallRonald KillianyRobert A SternThor D SteinAnn McKeeJesse MezMichael AloscoPublished in: Neurology (2022)
In brain donors with autopsy-confirmed AD, comorbid CBVD was associated with an accelerated functional and cognitive decline, particularly on neuropsychological tests of attention, psychomotor speed, and working memory. CBVD magnified effects of AD neuropathology on semantic-related neuropsychological tasks. Findings support a prominent additive and more subtle synergistic effect for comorbid CBVD neuropathology in AD.